A Giant Mixed Infiltrative Angiolipoma of the Back with Venous Malformation- A Case Report and Related Gene Mutation Detection

Abstract

Fangning Zhao,* Zhenyu Yang,* Xiaonan Yang The Department of Hemangioma and Vascular Malformation, Plastic Surgery Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaonan Yang, Email [email protected]: We report a case of a middle-aged male patient with a diffuse large mixed infiltrating angiolipoma on the back with venous malformation that grew from the age of 3 years. We discussed the design of the surgical flap for this large lipoma, observed its blood supply using SPY, and screened for possible causative genes, FCGR2A, BMP5, MUC2, and KRTAP4-9. To date, no invasive lipomas of this size and duration have been reported.Keywords: case report, lipoma, infiltrating lipoma, SPY, gene detection, whole-exome sequencing

Keywords

• case report
• lipoma
• infiltrating lipoma
• spy
• gene detection
• whole-exome sequencing