PARALLELS BETWEEN THE HEMODYNAMIC PROFILE AND BIOMARKERS ACTIVITY IN DIFFERENT FORMS OF ACUTE HEART FAILURE IN THE EARLY PERIOD AFTER AORTOCORONARY BYPASS

Abstract

Goal: to study the rates of central hemodynamics and clinical progress and to evaluate the activity of biomarkers of myocarditis overload and damage in patients with isolated reduction of systolic function of right or left ventricle in early period after aortocoronary bypass. 25 patients were enrolled into the study (14 men, 11 women, average age 58 ± 7 years), admitted to the intensive care department after aortocoronary bypass with artificial circulation and in need of inotropic therapy. Rates of central hemodymanics were monitored with the help of PiCCO system and VoLEF additional module. Blood was collected to assess the NT-proBNP level in 1 and 24 hours from the admission to the intensive care department, and tropinin I level - in 24 hours. It has been found out that the acute heart failure in early period after aortoconorary bypass was associated with isolated systolic dysfunction of right ventricle in 40% of cases, with left ventricle in 32% and in 28% it was of bi-ventricular nature. Failure of right ventricle requires a continuous rehabilitation period and bigger activity pf NT-proBNR compared to the left ventricle failure while the troponin I level does not confidently differ for these groups.

Keywords

• acute cardiac failure
• inotropic therapy
• conorary bypass
• nt-probnp