Elk1 enhances inflammatory cell infiltration and exacerbates acute lung injury/acute respiratory distress syndrome by suppressing Fcgr2b transcription

Shiyou Wei; Dandan Ling; Jingui Zhong; Rui Chang; Xinyu Ling; Zhigang Chen; Ruowang Duan

doi:10.1186/s10020-024-00820-z

Molecular Medicine (Apr 2024)

Elk1 enhances inflammatory cell infiltration and exacerbates acute lung injury/acute respiratory distress syndrome by suppressing Fcgr2b transcription

Shiyou Wei,
Dandan Ling,
Jingui Zhong,
Rui Chang,
Xinyu Ling,
Zhigang Chen,
Ruowang Duan

Affiliations

Shiyou Wei: Department of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University
Dandan Ling: Department of Anesthesiology, Fudan University Shanghai Cancer Center
Jingui Zhong: Department of General Surgery, Zhabei Central Hospital of Jing’an District
Rui Chang: Medical department, Shanghai Pulmonary Hospital, School of Medicine, Tongji University
Xinyu Ling: Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University
Zhigang Chen: Department of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University
Ruowang Duan: Department of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University

DOI: https://doi.org/10.1186/s10020-024-00820-z
Journal volume & issue: Vol. 30, no. 1
pp. 1 – 14

Abstract

Read online

Highlights LPS-induced ARDS rats and PMVECs have low Fcgr2b level and high Elk1 level; Fcgr2b overexpression mitigates LPS-induced ALI/ARDS in rats and PMVECs; Elk1 knockdown mitigates LPS-induced ALI/ARDS in rats and PMVECs; Elk1 represses Fcgr2b transcription by recruiting H3K9me3; Elk1/Fcgr2b axis aggravates LPS-induced ALI/ARDS in rats and PMVECs.

Published in Molecular Medicine

ISSN: 1076-1551 (Print); 1528-3658 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Therapeutics. Pharmacology; Science: Chemistry: Organic chemistry: Biochemistry
Website: https://molmed.biomedcentral.com

About the journal

Abstract

Keywords