Polyketide Derivatives, Guhypoxylonols A–D from a Mangrove Endophytic Fungus <i>Aspergillus</i> sp. GXNU-Y45 That Inhibit Nitric Oxide Production
Xiaoya Qin,
Jiguo Huang,
Dexiong Zhou,
Wenxiu Zhang,
Yanjun Zhang,
Jun Li,
Ruiyun Yang,
Xishan Huang
Affiliations
Xiaoya Qin
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, College of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541005, China
Jiguo Huang
School of Chemical Engineering and Technology, Guangdong Industry Polytechnic, Guangzhou 510300, China
Dexiong Zhou
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, College of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541005, China
Wenxiu Zhang
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, College of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541005, China
Yanjun Zhang
Guangxi Key Laboratory of Green Chemical Materials and Safety Technology, Beibu Gulf University, Qinzhou 535011, China
Jun Li
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, College of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541005, China
Ruiyun Yang
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, College of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541005, China
Xishan Huang
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, College of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541005, China
Four undescribed compounds, guhypoxylonols A (1), B (2), C (3), and D (4), were isolated from the mangrove endophytic fungus Aspergillus sp. GXNU-Y45, together with seven previously reported metabolites. The structures of 1–4 were elucidated based on analysis of HRESIMS and NMR spectroscopic data. The absolute configurations of the stereogenic carbons in 1–3 were established through a combination of spectroscopic data and electronic circular dichroism (ECD). Compounds 1–11 were evaluated for their anti-inflammatory activity. Compounds 1, 3, 4, and 6 showed an inhibitory activity against the production of nitric oxide (NO), with the IC50 values of 14.42 ± 0.11, 18.03 ± 0.14, 16.66 ± 0.21, and 21.05 ± 0.13 μM, respectively.
