Mediators of Inflammation (Jan 2016)

miRNAs Participate in MS Pathological Processes and Its Therapeutic Response

  • Ting Wu,
  • Guangjie Chen

DOI
https://doi.org/10.1155/2016/4578230
Journal volume & issue
Vol. 2016

Abstract

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Multiple sclerosis is the most common autoimmune disease of the central nervous system. It is believed that the increased migration of autoreactive lymphocytes across the blood-brain barrier (BBB) may be responsible for axonal demyelination of neurons. In this review, we discuss microRNAs participating in the pathological processes of MS, including periphery inflammation, blood-brain barrier disruption, and CNS lesions, and in its therapeutic response, in order to find biomarkers of disease severity and to predict the response to therapy of the diseases.