Acute myeloid leukemia with a ZMYND11::MBTD1 fusion gene following chemotherapy and radiotherapy for breast cancer: A case report

Hidetsugu Kawai; Sawako Shiraiwa; Daisuke Ogiya; Masako Toyosaki; Shinichiro Machida; Rikio Suzuki; Makoto Onizuka; Yoshiaki Ogawa; Hiroshi Kawada

Leukemia Research Reports (Jan 2024)

Acute myeloid leukemia with a ZMYND11::MBTD1 fusion gene following chemotherapy and radiotherapy for breast cancer: A case report

Hidetsugu Kawai,
Sawako Shiraiwa,
Daisuke Ogiya,
Masako Toyosaki,
Shinichiro Machida,
Rikio Suzuki,
Makoto Onizuka,
Yoshiaki Ogawa,
Hiroshi Kawada

Affiliations

Hidetsugu Kawai: Department of Hematology / Oncology, Tokai University School of Medicine, Isehara, Kanagawa, Japan; Department of Hematology, Hiratsuka Mutual Aid Hospital, Hiratsuka, Kanagawa, Japan
Sawako Shiraiwa: Department of Hematology / Oncology, Tokai University School of Medicine, Isehara, Kanagawa, Japan
Daisuke Ogiya: Department of Hematology / Oncology, Tokai University School of Medicine, Isehara, Kanagawa, Japan
Masako Toyosaki: Department of Hematology / Oncology, Tokai University School of Medicine, Isehara, Kanagawa, Japan
Shinichiro Machida: Department of Hematology / Oncology, Tokai University School of Medicine, Isehara, Kanagawa, Japan
Rikio Suzuki: Department of Hematology / Oncology, Tokai University School of Medicine, Isehara, Kanagawa, Japan
Makoto Onizuka: Department of Hematology / Oncology, Tokai University School of Medicine, Isehara, Kanagawa, Japan
Yoshiaki Ogawa: Department of Hematology / Oncology, Tokai University School of Medicine, Isehara, Kanagawa, Japan
Hiroshi Kawada: Department of Hematology / Oncology, Tokai University School of Medicine, Isehara, Kanagawa, Japan; Corresponding author: Hiroshi Kawada, Department of Hematology /Oncology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan.

Journal volume & issue: Vol. 22
p. 100478

Abstract

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The t(10;17)(p15;q21) translocation is a very rare recurrent cytogenetic aberration, and produced ZMYND11::MBTD1 fusion gene. To date, nine cases of acute leukemia with the t(10;17)(p15;q21) translocation have been reported, but the case of AML with ZMYND11::MBTD1 after chemotherapy and radiotherapy have not been reported. Epirubicin-based chemotherapy or radiotherapy for breast cancer increases the risk of developing secondary leukemia. We report a case of AML with the ZMYND11::MBTD1 fusion gene that developed after epirubicin-based chemotherapy and radiotherapy for breast cancer. previous chemotherapy and radiotherapy may be associated with poor prognosis of AML with ZMYND11/MBTD1.

Published in Leukemia Research Reports

ISSN: 2213-0489 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: http://www.journals.elsevier.com/leukemia-research-reports/

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