A new analytical method for the determination of iron content in drugs

Abstract

Objective: This study is based on the determination of iron, which is found in iron-containing drugs, by a simple, precise, and economical method.Methods: In our study, Flame Atomic Absorption Spectroscopy (FAAS) was used for measurements due to its ease of use and low cost. The disadvantage of FAAS in terms of insufficient precision was turned into an advantage by adding a slotted quartz tube (SQT) to the device and using an enrichment method. Accordingly, a solid-phase microextraction (SPME) method interconnected with slotted quartz tube-flame atomic absorption spectrometry (SQT-FAAS) was developed.Results: While the LOD value for Fe³⁺ ions measured by FAAS was 108.0 mg/L, the LOD value was determined to be 1.12 mg/L with the method developed using CoMNP-SPME-SQT. This indicates a 96.43-fold improvement in the LOD.Conclusion: The developed Co-MNP-DSPE-SQT-FAAS method has been successfully and easily applied for the determination of iron in iron-containing drug samples. These results indicate that the method can also be applied to different samples.

Keywords

• manyetik nanoparçacık-katı faz mikroekstraksiyonu (mnpspme)
• demir
• i̇laç
• alevli atomik absorpsiyon spektroskopisi (faas)
• magnetic nanoparticle-solid phase microextraction (mnpspme)
• iron
• drug
• flame atomic absorption spectroscopy (faas)