Pingyin rose essential oil alleviates LPS-Induced inflammation in RAW 264.7 cells via the NF-κB pathway: an integrated in vitro and network pharmacology analysis

Abstract

Highlights ➢ PREO is a mixture of aromatic components, mainly monoterpenoids. ➢ PREO reduces the expression of proinflammatory cytokines and oxidative stress markers. ➢ Network pharmacological studies indicated that PREO might downregulate inflammation through the NF-κB signaling pathway, and these results were confirmed by Western blot investigation. ➢ Molecular docking analysis revealed the potential of these compounds as possible ligands. Graphical Abstract

Keywords

• Rosa rugosa cv. Plena
• Essential oil
• Anti-inflammation
• Oxidative stress
• NF-κB signaling
• Network Pharmacology