Nature Communications (Feb 2023)
Shark nanobodies with potent SARS-CoV-2 neutralizing activity and broad sarbecovirus reactivity
- Wei-Hung Chen,
- Agnes Hajduczki,
- Elizabeth J. Martinez,
- Hongjun Bai,
- Hanover Matz,
- Thomas M. Hill,
- Eric Lewitus,
- William C. Chang,
- Layla Dawit,
- Caroline E. Peterson,
- Phyllis A. Rees,
- Adelola B. Ajayi,
- Emily S. Golub,
- Isabella Swafford,
- Vincent Dussupt,
- Sapna David,
- Sandra V. Mayer,
- Sandrine Soman,
- Caitlin Kuklis,
- Courtney Corbitt,
- Jocelyn King,
- Misook Choe,
- Rajeshwer S. Sankhala,
- Paul V. Thomas,
- Michelle Zemil,
- Lindsay Wieczorek,
- Tricia Hart,
- Debora Duso,
- Larry Kummer,
- Lianying Yan,
- Spencer L. Sterling,
- Eric D. Laing,
- Christopher C. Broder,
- Jazmean K. Williams,
- Edgar Davidson,
- Benjamin J. Doranz,
- Shelly J. Krebs,
- Victoria R. Polonis,
- Dominic Paquin-Proulx,
- Morgane Rolland,
- William W. Reiley,
- Gregory D. Gromowski,
- Kayvon Modjarrad,
- Helen Dooley,
- M. Gordon Joyce
Affiliations
- Wei-Hung Chen
- Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research
- Agnes Hajduczki
- Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research
- Elizabeth J. Martinez
- Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research
- Hongjun Bai
- Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research
- Hanover Matz
- Department of Microbiology and Immunology, University of Maryland School of Medicine
- Thomas M. Hill
- Department of Microbiology and Immunology, University of Maryland School of Medicine
- Eric Lewitus
- Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research
- William C. Chang
- Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research
- Layla Dawit
- Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research
- Caroline E. Peterson
- Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research
- Phyllis A. Rees
- Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research
- Adelola B. Ajayi
- Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research
- Emily S. Golub
- Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research
- Isabella Swafford
- Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research
- Vincent Dussupt
- Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research
- Sapna David
- Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research
- Sandra V. Mayer
- Henry M. Jackson Foundation for the Advancement of Military Medicine
- Sandrine Soman
- Viral Diseases Branch, Walter Reed Army Institute of Research
- Caitlin Kuklis
- Viral Diseases Branch, Walter Reed Army Institute of Research
- Courtney Corbitt
- Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research
- Jocelyn King
- Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research
- Misook Choe
- Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research
- Rajeshwer S. Sankhala
- Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research
- Paul V. Thomas
- Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research
- Michelle Zemil
- U.S. Military HIV Research Program, Walter Reed Army Institute of Research
- Lindsay Wieczorek
- Henry M. Jackson Foundation for the Advancement of Military Medicine
- Tricia Hart
- Trudeau Institute
- Debora Duso
- Trudeau Institute
- Larry Kummer
- Trudeau Institute
- Lianying Yan
- Department of Microbiology and Immunology, Uniformed Services University
- Spencer L. Sterling
- Department of Microbiology and Immunology, Uniformed Services University
- Eric D. Laing
- Department of Microbiology and Immunology, Uniformed Services University
- Christopher C. Broder
- Department of Microbiology and Immunology, Uniformed Services University
- Jazmean K. Williams
- Integral Molecular
- Edgar Davidson
- Integral Molecular
- Benjamin J. Doranz
- Integral Molecular
- Shelly J. Krebs
- Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research
- Victoria R. Polonis
- U.S. Military HIV Research Program, Walter Reed Army Institute of Research
- Dominic Paquin-Proulx
- Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research
- Morgane Rolland
- Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research
- William W. Reiley
- Trudeau Institute
- Gregory D. Gromowski
- Viral Diseases Branch, Walter Reed Army Institute of Research
- Kayvon Modjarrad
- Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research
- Helen Dooley
- Department of Microbiology and Immunology, University of Maryland School of Medicine
- M. Gordon Joyce
- Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research
- DOI
- https://doi.org/10.1038/s41467-023-36106-x
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 18
Abstract
SARS-CoV-2 variants of concern continue to emerge, reducing vaccine efficacy and limiting therapeutic options. Here, Chen and colleagues describe the identification and design of shark nanobodies with pansarbecovirus activity.
