A protocol for the stereoselective synthesis of a Star of David [2]catenane

Weitao Ye; Hai-Na Feng; Zhi-Hui Zhang; Liang Zhang

STAR Protocols (Mar 2024)

A protocol for the stereoselective synthesis of a Star of David [2]catenane

Weitao Ye,
Hai-Na Feng,
Zhi-Hui Zhang,
Liang Zhang

Affiliations

Weitao Ye: School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, P.R. China; School Frontiers Science Center of Molecular Intelligent Synthesis, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, P.R. China
Hai-Na Feng: School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, P.R. China; School Frontiers Science Center of Molecular Intelligent Synthesis, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, P.R. China
Zhi-Hui Zhang: School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, P.R. China; School Frontiers Science Center of Molecular Intelligent Synthesis, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, P.R. China; Corresponding author
Liang Zhang: School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, P.R. China; School Frontiers Science Center of Molecular Intelligent Synthesis, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, P.R. China; Corresponding author

Journal volume & issue: Vol. 5, no. 1
p. 102821

Abstract

Read online

Summary: Most complex prime links exhibit inherent topological chirality, yet their high stereoinduction remains a rare occurrence. Here, we present a protocol for the stereoselective synthesis of a molecular link comprising two triple entwined rings. We describe steps for constructing the precursor circular helicate, performing ring closure metathesis, and demetallation. We also outline procedures for bio-beads separation and data analysis. This protocol holds promise for applications in molecular nanotopology.For complete details on the use and execution of this protocol, please refer to Zhang et al. (2022).1 : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.

Published in STAR Protocols

ISSN: 2666-1667 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science: Science (General)
Website: https://star-protocols.cell.com/

About the journal

Abstract

Keywords