Maximizing the ovarian reserve in mice by evading LINE-1 genotoxicity

Marla E. Tharp; Safia Malki; Alex Bortvin

doi:10.1038/s41467-019-14055-8

Nature Communications (Jan 2020)

Maximizing the ovarian reserve in mice by evading LINE-1 genotoxicity

Marla E. Tharp,
Safia Malki,
Alex Bortvin

Affiliations

Marla E. Tharp: Department of Embryology, Carnegie Institution for Science
Safia Malki: Department of Embryology, Carnegie Institution for Science
Alex Bortvin: Department of Embryology, Carnegie Institution for Science

DOI: https://doi.org/10.1038/s41467-019-14055-8
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 13

Abstract

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Mammals lose up to 80% of their finite oocyte supply during fetal development. Here the authors interrogate mechanisms of fetal oocyte attrition in mice, driven by the simultaneous upregulation of LINE-1 retrotransposon activity and inhibit these mechanisms to increase the functional ovarian reserve.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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