IL-33 expression in response to SARS-CoV-2 correlates with seropositivity in COVID-19 convalescent individuals

Michal A. Stanczak; David E. Sanin; Petya Apostolova; Gabriele Nerz; Dimitrios Lampaki; Maike Hofmann; Daniel Steinmann; Marvin Krohn-Grimberghe; Robert Thimme; Gerhard Mittler; Cornelius F. Waller; Edward J. Pearce; Erika L. Pearce

doi:10.1038/s41467-021-22449-w

Nature Communications (Apr 2021)

IL-33 expression in response to SARS-CoV-2 correlates with seropositivity in COVID-19 convalescent individuals

Michal A. Stanczak,
David E. Sanin,
Petya Apostolova,
Gabriele Nerz,
Dimitrios Lampaki,
Maike Hofmann,
Daniel Steinmann,
Marvin Krohn-Grimberghe,
Robert Thimme,
Gerhard Mittler,
Cornelius F. Waller,
Edward J. Pearce,
Erika L. Pearce

Affiliations

Michal A. Stanczak: Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics
David E. Sanin: Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics
Petya Apostolova: Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics
Gabriele Nerz: Proteomics, Max Planck Institute of Immunobiology and Epigenetics
Dimitrios Lampaki: Proteomics, Max Planck Institute of Immunobiology and Epigenetics
Maike Hofmann: Department of Medicine II, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg
Daniel Steinmann: Occupational Medical Service, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg
Marvin Krohn-Grimberghe: Department of Cardiology and Angiology I, University Heart Center Freiburg
Robert Thimme: Department of Medicine II, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg
Gerhard Mittler: Proteomics, Max Planck Institute of Immunobiology and Epigenetics
Cornelius F. Waller: Department of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg
Edward J. Pearce: Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics
Erika L. Pearce: Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics

DOI: https://doi.org/10.1038/s41467-021-22449-w
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 9

Abstract

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Our understanding of the immune response to SARS-CoV-2 infection is still incomplete. Here, the authors find that IL-33, produced during immune recall potentially by CD14+ monocytes, correlates with CD4+ T cell activation, anti-SARS-CoV-2 antibody titer, and disease severity in a cohort of convalescent individuals professionally exposed to the virus.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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