Biomedicines (Sep 2024)
Evaluation of Viral Suppression in Paediatric Populations: Implications for the Transition to Dolutegravir-Based Regimens in Cameroon: The CIPHER-ADOLA Study
- Joseph Fokam,
- Yagai Bouba,
- Rogers Awoh Ajeh,
- Dominik Tameza Guebiapsi,
- Suzane Essamba,
- Albert Franck Zeh Meka,
- Ebiama Lifanda,
- Rose Armelle Ada,
- Liman Yakouba,
- Nancy Barbara Mbengono,
- Audrey Raissa Dzaddi Djomo,
- Suzie Ndiang Tetang,
- Samuel Martin Sosso,
- Jocelyne Carmen Babodo,
- Olivia Francette Ndomo Ambomo,
- Edith Michele Temgoua,
- Caroline Medouane,
- Sabine Ndejo Atsinkou,
- Justin Leonel Mvogo,
- Roger Martin Onana,
- Jean de Dieu Anoubissi,
- Alice Ketchaji,
- Alex Durand Nka,
- Davy-Hyacinthe Anguechia Gouissi,
- Aude Christelle Ka’e,
- Nadine Nguendjoung Fainguem,
- Rachel Simo Kamgaing,
- Désiré Takou,
- Michel Carlos Tommo Tchouaket,
- Ezechiel Ngoufack Jagni Semengue,
- Marie Amougou Atsama,
- Julius Nwobegahay,
- Comfort Vuchas,
- Anna Nya Nsimen,
- Bertrand Eyoum Bille,
- Sandra kenmegne Gatchuessi,
- Francis Ndongo Ateba,
- Daniel Kesseng,
- Serge Clotaire Billong,
- Daniele Armenia,
- Maria Mercedes Santoro,
- Francesca Ceccherini-Silberstein,
- Paul Ndombo Koki,
- Hadja Cherif Hamsatou,
- Vittorio Colizzi,
- Alexis Ndjolo,
- Carlo-Federico Perno,
- Anne-Cecile Zoung-Kanyi Bissek
Affiliations
- Joseph Fokam
- Faculty of Health Sciences, University of Buea, Buea P.O. Box 63, Cameroon
- Yagai Bouba
- Chantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé P.O. Box 3077, Cameroon
- Rogers Awoh Ajeh
- Faculty of Health Sciences, University of Buea, Buea P.O. Box 63, Cameroon
- Dominik Tameza Guebiapsi
- Central Technical Group, National AIDS Control Committee (NACC), Yaoundé P.O. Box 2459, Cameroon
- Suzane Essamba
- Central Technical Group, National AIDS Control Committee (NACC), Yaoundé P.O. Box 2459, Cameroon
- Albert Franck Zeh Meka
- Central Technical Group, National AIDS Control Committee (NACC), Yaoundé P.O. Box 2459, Cameroon
- Ebiama Lifanda
- Health Office, United States Agency for International Development (USAID), Yaoundé P.O. Box 817, Cameroon
- Rose Armelle Ada
- Central Technical Group, National AIDS Control Committee (NACC), Yaoundé P.O. Box 2459, Cameroon
- Liman Yakouba
- Central Technical Group, National AIDS Control Committee (NACC), Yaoundé P.O. Box 2459, Cameroon
- Nancy Barbara Mbengono
- Central Technical Group, National AIDS Control Committee (NACC), Yaoundé P.O. Box 2459, Cameroon
- Audrey Raissa Dzaddi Djomo
- Health Office, United States Agency for International Development (USAID), Yaoundé P.O. Box 817, Cameroon
- Suzie Ndiang Tetang
- Essos Hospital (CHE), National Social Welfare Centre, Yaoundé P.O. Box 5777, Cameroon
- Samuel Martin Sosso
- Chantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé P.O. Box 3077, Cameroon
- Jocelyne Carmen Babodo
- Central Technical Group, National AIDS Control Committee (NACC), Yaoundé P.O. Box 2459, Cameroon
- Olivia Francette Ndomo Ambomo
- Central Technical Group, National AIDS Control Committee (NACC), Yaoundé P.O. Box 2459, Cameroon
- Edith Michele Temgoua
- Central Technical Group, National AIDS Control Committee (NACC), Yaoundé P.O. Box 2459, Cameroon
- Caroline Medouane
- Central Technical Group, National AIDS Control Committee (NACC), Yaoundé P.O. Box 2459, Cameroon
- Sabine Ndejo Atsinkou
- Central Technical Group, National AIDS Control Committee (NACC), Yaoundé P.O. Box 2459, Cameroon
- Justin Leonel Mvogo
- Central Technical Group, National AIDS Control Committee (NACC), Yaoundé P.O. Box 2459, Cameroon
- Roger Martin Onana
- Central Technical Group, National AIDS Control Committee (NACC), Yaoundé P.O. Box 2459, Cameroon
- Jean de Dieu Anoubissi
- Central Technical Group, National AIDS Control Committee (NACC), Yaoundé P.O. Box 2459, Cameroon
- Alice Ketchaji
- Division of Disease, Epidemic and Pandemic Control, Ministry of Public Health, Yaoundé P.O. Box 3038, Cameroon
- Alex Durand Nka
- Chantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé P.O. Box 3077, Cameroon
- Davy-Hyacinthe Anguechia Gouissi
- Chantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé P.O. Box 3077, Cameroon
- Aude Christelle Ka’e
- Chantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé P.O. Box 3077, Cameroon
- Nadine Nguendjoung Fainguem
- Chantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé P.O. Box 3077, Cameroon
- Rachel Simo Kamgaing
- Chantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé P.O. Box 3077, Cameroon
- Désiré Takou
- Chantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé P.O. Box 3077, Cameroon
- Michel Carlos Tommo Tchouaket
- Chantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé P.O. Box 3077, Cameroon
- Ezechiel Ngoufack Jagni Semengue
- Chantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé P.O. Box 3077, Cameroon
- Marie Amougou Atsama
- Research Center on Emerging and Re-Emerging Diseases (CREMER), Yaoundé P.O. Box 13033, Cameroon
- Julius Nwobegahay
- Centre for Research and Military Health (CRESAR), Yaoundé P.O. Box 15939, Cameroon
- Comfort Vuchas
- The Bamenda Center for Health Promotion and Research, Bamenda P.O. Box 586, Cameroon
- Anna Nya Nsimen
- The Bamenda Center for Health Promotion and Research, Bamenda P.O. Box 586, Cameroon
- Bertrand Eyoum Bille
- Retrovirology Laboratory, Laquintinie Hospital, Douala P.O. Box 4035, Cameroon
- Sandra kenmegne Gatchuessi
- Fondation Sociale Suisse, Pette Hospital, Pette P.O. Box 65, Cameroon
- Francis Ndongo Ateba
- Mother-Child Centre, Chantal BIYA Foundation, Yaoundé P.O. Box 1936, Cameroon
- Daniel Kesseng
- Mother-Child Centre, Chantal BIYA Foundation, Yaoundé P.O. Box 1936, Cameroon
- Serge Clotaire Billong
- Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé P.O. Box 1364, Cameroon
- Daniele Armenia
- Faculty of Medicine, UniCamillus—Saint Camillus International University of Health Sciences, 00131 Rome, Italy
- Maria Mercedes Santoro
- Department of Experimental Medicine, University of Rome “Tor Vergata”, 00133 Rome, Italy
- Francesca Ceccherini-Silberstein
- Department of Experimental Medicine, University of Rome “Tor Vergata”, 00133 Rome, Italy
- Paul Ndombo Koki
- Mother-Child Centre, Chantal BIYA Foundation, Yaoundé P.O. Box 1936, Cameroon
- Hadja Cherif Hamsatou
- Central Technical Group, National AIDS Control Committee (NACC), Yaoundé P.O. Box 2459, Cameroon
- Vittorio Colizzi
- Faculty of Science and Technology, University of Bandjoun, Bandjoun P.O. Box 127, Cameroon
- Alexis Ndjolo
- Chantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé P.O. Box 3077, Cameroon
- Carlo-Federico Perno
- Multimodal Medicine Laboratory, Bambino Gesù Children Hospital, IRCCS, 00165 Rome, Italy
- Anne-Cecile Zoung-Kanyi Bissek
- Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé P.O. Box 1364, Cameroon
- DOI
- https://doi.org/10.3390/biomedicines12092083
- Journal volume & issue
-
Vol. 12,
no. 9
p. 2083
Abstract
Mortality in children accounts for 15% of all AIDS-related deaths globally, with a higher burden among Cameroonian children (25%), likely driven by poor virological response. We sought to evaluate viral suppression (VS) and its determinants in a nationally representative paediatric and young adult population receiving antiretroviral therapy (ART). A cross-sectional and multicentric study was conducted among Cameroonian children (p p p 36 months), backbone drug (non-TDF/3TC) and anchor drug (non-DTG based). In this Cameroonian paediatric population with varying levels of transition to DTG, overall VS remains below the 95% targets. Predictors of non-VS are younger age, non-TDF/3TC- and non-DTG-based regimens. Thus, efforts toward eliminating paediatric AIDS should prioritise the transition to a DTG-based regimen in this new ART era.
Keywords
