Flavonoids green tea against oxidant stress and inflammation with related human diseases

Abstract

Summary: The liver is the most important organ and may be regarded as the metabolic entry point of the body. It contributes the metabolism of nutrients, endobiotics and drug/xenobiotics with absolute efficacy. It performs anabolic enrichment of the larger-molecule to generate more calorific storage-materials. At the same time, catabolic end-products of hundreds of molecules are either recycled or efficiently excreted by this organ. The strongest drug-metabolizing enzymatic machinery helps this organ to fight thousands of molecules. Chronic/acute-toxicity, metabolic-syndrome, oxidative-stress, inflammatory-responses and mutagenesis carcinogenesis severely challenge this organ and make the situation life-threatening. At a severe condition during hepatitis, fatty-liver syndrome, cirrhosis, fibrotic-liver damage end-stage situation arise. Present report suggests that green tea and its constituents offer the strongest herbal remedy/therapy in liver anomalies. A large number of polyphenols with the effective galloyl group, several instaurations, hydroxyl groups and other structural specialty attribute to its antioxidant, anti-inflammatory, anti-proliferative, anti-mutagenic/anti-carcinogenic potentials. Green tea has been shown to offer its protections at cellular, biochemical and molecular levels influencing a large number of metabolic pathways. Keywords: Oxidative stress, Metabolic syndrome, Liver carcinogenesis, Camellia sinensis, Anti-oxidative and anti-carcinogenic role