Emr1 regulates the number of foci of the endoplasmic reticulum-mitochondria encounter structure complex

Faiz Rasul; Fan Zheng; Fenfen Dong; Jiajia He; Ling Liu; Wenyue Liu; Javairia Yousuf Cheema; Wenfan Wei; Chuanhai Fu

doi:10.1038/s41467-020-20866-x

Nature Communications (Jan 2021)

Emr1 regulates the number of foci of the endoplasmic reticulum-mitochondria encounter structure complex

Faiz Rasul,
Fan Zheng,
Fenfen Dong,
Jiajia He,
Ling Liu,
Wenyue Liu,
Javairia Yousuf Cheema,
Wenfan Wei,
Chuanhai Fu

Affiliations

Faiz Rasul: Ministry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics, CAS Center for Excellence in Molecular Cell Sciences, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China
Fan Zheng: Ministry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics, CAS Center for Excellence in Molecular Cell Sciences, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China
Fenfen Dong: Ministry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics, CAS Center for Excellence in Molecular Cell Sciences, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China
Jiajia He: Ministry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics, CAS Center for Excellence in Molecular Cell Sciences, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China
Ling Liu: Ministry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics, CAS Center for Excellence in Molecular Cell Sciences, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China
Wenyue Liu: Ministry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics, CAS Center for Excellence in Molecular Cell Sciences, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China
Javairia Yousuf Cheema: Ministry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics, CAS Center for Excellence in Molecular Cell Sciences, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China
Wenfan Wei: Ministry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics, CAS Center for Excellence in Molecular Cell Sciences, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China
Chuanhai Fu: Ministry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics, CAS Center for Excellence in Molecular Cell Sciences, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China

DOI: https://doi.org/10.1038/s41467-020-20866-x
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 14

Abstract

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Interorganelle membrane contact sites between the endoplasmic reticulum and mitochondria can be mediated with the ER-mitochondria encounter structure (ERMES) complex, though precise regulation is unclear. Here, the authors report that the number of ERMES foci is regulated by the previously uncharacterized mitochondrial membrane protein Emr1.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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