Oral Ulceration Due to Methotrexate Treatment: A Report of 3 Cases and Literature Review

Abstract

Methotrexate (MTX) is an antimetabolite which interferes with DNA synthesis. It is used for the treatment of many diseases, such as psoriasis, rheumatoid arthritis and various neoplastic diseases. It may cause, among various adverse reactions, oral ulceration and oral mucositis. 3 cases of methotrexate related oral ulcers are reported along with a brief review of the relevant literature.

Keywords

• oral ulceration
• methotrexate
• rheumatoid arthritis
• psoriatic arthritis