Nature Communications (Dec 2022)
Prior exposure to B. pertussis shapes the mucosal antibody response to acellular pertussis booster vaccination
- Evi van Schuppen,
- Janeri Fröberg,
- Prashanna Balaji Venkatasubramanian,
- Pauline Versteegen,
- Hans de Graaf,
- Jana Holubová,
- Joshua Gillard,
- Pieter G. M. van Gageldonk,
- Irma Joosten,
- Ronald de Groot,
- Peter Šebo,
- Guy A. M. Berbers,
- Robert C. Read,
- Martijn A. Huynen,
- Marien I. de Jonge,
- Dimitri A. Diavatopoulos
Affiliations
- Evi van Schuppen
- Laboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences, Radboudumc
- Janeri Fröberg
- Laboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences, Radboudumc
- Prashanna Balaji Venkatasubramanian
- Center for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboudumc
- Pauline Versteegen
- National Institute for Public Health and the Environment, Centre for Infectious Disease Control
- Hans de Graaf
- Faculty of Medicine and Institute for Life Sciences, University of Southampton, Academic Unit of Clinical Experimental Sciences, National Institute of Health Research (NIHR) Clinical Research Facility and NIHR Southampton Biomedical Research Centre, University Hospital Southampton
- Jana Holubová
- Institute of Microbiology of the Czech Academy of Sciences
- Joshua Gillard
- Laboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences, Radboudumc
- Pieter G. M. van Gageldonk
- National Institute for Public Health and the Environment, Centre for Infectious Disease Control
- Irma Joosten
- Laboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences, Radboudumc
- Ronald de Groot
- Laboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences, Radboudumc
- Peter Šebo
- Institute of Microbiology of the Czech Academy of Sciences
- Guy A. M. Berbers
- National Institute for Public Health and the Environment, Centre for Infectious Disease Control
- Robert C. Read
- Faculty of Medicine and Institute for Life Sciences, University of Southampton, Academic Unit of Clinical Experimental Sciences, National Institute of Health Research (NIHR) Clinical Research Facility and NIHR Southampton Biomedical Research Centre, University Hospital Southampton
- Martijn A. Huynen
- Center for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboudumc
- Marien I. de Jonge
- Laboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences, Radboudumc
- Dimitri A. Diavatopoulos
- Laboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences, Radboudumc
- DOI
- https://doi.org/10.1038/s41467-022-35165-w
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 11
Abstract
Bordetella pertussis (Bp), the causative agent of pertussis, continues to circulate and it’s not well understood how (sub)clinical infections shape immune memory to Bp and vaccination. Here, using a mutant Bp strain lacking antigens of the acellular pertussis vaccine, the authors show how prior exposure to Bp shapes the mucosal antibody response to booster vaccination.
