A minimal biochemical route towards de novo formation of synthetic phospholipid membranes

Ahanjit Bhattacharya; Roberto J. Brea; Henrike Niederholtmeyer; Neal K. Devaraj

doi:10.1038/s41467-018-08174-x

Nature Communications (Jan 2019)

A minimal biochemical route towards de novo formation of synthetic phospholipid membranes

Ahanjit Bhattacharya,
Roberto J. Brea,
Henrike Niederholtmeyer,
Neal K. Devaraj

Affiliations

Ahanjit Bhattacharya: Department of Chemistry and Biochemistry, University of California
Roberto J. Brea: Department of Chemistry and Biochemistry, University of California
Henrike Niederholtmeyer: Department of Chemistry and Biochemistry, University of California
Neal K. Devaraj: Department of Chemistry and Biochemistry, University of California

DOI: https://doi.org/10.1038/s41467-018-08174-x
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 8

Abstract

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The origin of phospholipids, the primary constituents of cell membranes, is uncertain. Here, the authors develop an in vitro system to synthesize phospholipid molecules from water-soluble single-chain amphiphilic precursors via a reaction catalysed by the mycobacterial ligase FadD10.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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