Epithelial barrier dysfunction in bronchial asthma

Abstract

The pathogenesis of bronchial asthma is based on chronic inflammation as a response to etiological factors. It causes bron-chial hyperreactivity, remodeling of the respiratory tract and hypersecretion of mucus. Epithelial damage is a pathological sign observed in all bronchial asthma phenotypes. The purpose of this review: to analyze changes in the epithelial barrier in bronchial asthma, to reflect potential therapeutic ways of exposure. Changes in the epithelial barrier include a violation of the ratio of mucins (MUC5AC to MUC5B), violations of intercellular connections when exposed to allergens, infectious agents, suspended particles. Currently, various diagnostic approaches are being developed to detect epithelial barrier dysfunction. Exposure to the epithelial barrier of the respiratory tract may be a promising new therapeutic strategy for asthma and related allergic diseases. The preservation or restoration of the function of the air-way barrier is a new area of respiratory diseases that requires extensive further research.

Keywords

• epithelial barrier
• dysfunction
• bronchial asthma