Tissue-specific impacts of aging and genetics on gene expression patterns in humans

Ryo Yamamoto; Ryan Chung; Juan Manuel Vazquez; Huanjie Sheng; Philippa L. Steinberg; Nilah M. Ioannidis; Peter H. Sudmant

doi:10.1038/s41467-022-33509-0

Nature Communications (Oct 2022)

Tissue-specific impacts of aging and genetics on gene expression patterns in humans

Ryo Yamamoto,
Ryan Chung,
Juan Manuel Vazquez,
Huanjie Sheng,
Philippa L. Steinberg,
Nilah M. Ioannidis,
Peter H. Sudmant

Affiliations

Ryo Yamamoto: Department of Integrative Biology, University of California Berkeley
Ryan Chung: Center for Computational Biology, University of California Berkeley
Juan Manuel Vazquez: Department of Integrative Biology, University of California Berkeley
Huanjie Sheng: Department of Integrative Biology, University of California Berkeley
Philippa L. Steinberg: Department of Integrative Biology, University of California Berkeley
Nilah M. Ioannidis: Center for Computational Biology, University of California Berkeley
Peter H. Sudmant: Department of Integrative Biology, University of California Berkeley

DOI: https://doi.org/10.1038/s41467-022-33509-0
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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Age is a risk factor for many diseases, but the impact of aging on molecular phenotypes is not fully understood. Here, the authors quantify the relative contributions of genetics and aging to gene expression patterns across 27 tissues in humans, showing that age and genetics each play distinct roles in shaping expression phenotypes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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