Nature Communications (May 2020)
ISG15 and ISGylation is required for pancreatic cancer stem cell mitophagy and metabolic plasticity
- Sonia Alcalá,
- Patricia Sancho,
- Paola Martinelli,
- Diego Navarro,
- Coral Pedrero,
- Laura Martín-Hijano,
- Sandra Valle,
- Julie Earl,
- Macarena Rodríguez-Serrano,
- Laura Ruiz-Cañas,
- Katerin Rojas,
- Alfredo Carrato,
- Laura García-Bermejo,
- Miguel Ángel Fernández-Moreno,
- Patrick C. Hermann,
- Bruno Sainz
Affiliations
- Sonia Alcalá
- Department of Biochemistry, Universidad Autónoma de Madrid (UAM) and Instituto de Investigaciones Biomédicas “Alberto Sols” (IIBM), CSIC-UAM
- Patricia Sancho
- IIS Aragón, Hospital Universitario Miguel Servet
- Paola Martinelli
- Institute for Cancer Research, Comprehensive Cancer Center, Medical University Vienna
- Diego Navarro
- Department of Biochemistry, Universidad Autónoma de Madrid (UAM) and Instituto de Investigaciones Biomédicas “Alberto Sols” (IIBM), CSIC-UAM
- Coral Pedrero
- Department of Biochemistry, Universidad Autónoma de Madrid (UAM) and Instituto de Investigaciones Biomédicas “Alberto Sols” (IIBM), CSIC-UAM
- Laura Martín-Hijano
- Department of Biochemistry, Universidad Autónoma de Madrid (UAM) and Instituto de Investigaciones Biomédicas “Alberto Sols” (IIBM), CSIC-UAM
- Sandra Valle
- Department of Biochemistry, Universidad Autónoma de Madrid (UAM) and Instituto de Investigaciones Biomédicas “Alberto Sols” (IIBM), CSIC-UAM
- Julie Earl
- Chronic Diseases and Cancer Area 3—Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS)
- Macarena Rodríguez-Serrano
- Biomarkers and Therapeutic Targets Group—IRYCIS
- Laura Ruiz-Cañas
- Department of Biochemistry, Universidad Autónoma de Madrid (UAM) and Instituto de Investigaciones Biomédicas “Alberto Sols” (IIBM), CSIC-UAM
- Katerin Rojas
- Department of Biochemistry, Universidad Autónoma de Madrid (UAM) and Instituto de Investigaciones Biomédicas “Alberto Sols” (IIBM), CSIC-UAM
- Alfredo Carrato
- Chronic Diseases and Cancer Area 3—Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS)
- Laura García-Bermejo
- Biomarkers and Therapeutic Targets Group—IRYCIS
- Miguel Ángel Fernández-Moreno
- Department of Biochemistry, Universidad Autónoma de Madrid (UAM) and Instituto de Investigaciones Biomédicas “Alberto Sols” (IIBM), CSIC-UAM
- Patrick C. Hermann
- Department of Internal Medicine I, Ulm University
- Bruno Sainz
- Department of Biochemistry, Universidad Autónoma de Madrid (UAM) and Instituto de Investigaciones Biomédicas “Alberto Sols” (IIBM), CSIC-UAM
- DOI
- https://doi.org/10.1038/s41467-020-16395-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
The ubiquitin-like modifier ISG15 exerts post-translational protein regulation through ISGylation. Here, the authors show that ISGylation is necessary for pancreatic cancer stem cell self-renewal and tumourigenesis by supporting the recycling of non-functional mitochondria.
