Nature Communications (Jun 2022)
Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets
- Benjamin A. Nacev,
- Francisco Sanchez-Vega,
- Shaleigh A. Smith,
- Cristina R. Antonescu,
- Evan Rosenbaum,
- Hongyu Shi,
- Cerise Tang,
- Nicholas D. Socci,
- Satshil Rana,
- Rodrigo Gularte-Mérida,
- Ahmet Zehir,
- Mrinal M. Gounder,
- Timothy G. Bowler,
- Anisha Luthra,
- Bhumika Jadeja,
- Azusa Okada,
- Jonathan A. Strong,
- Jake Stoller,
- Jason E. Chan,
- Ping Chi,
- Sandra P. D’Angelo,
- Mark A. Dickson,
- Ciara M. Kelly,
- Mary Louise Keohan,
- Sujana Movva,
- Katherine Thornton,
- Paul A. Meyers,
- Leonard H. Wexler,
- Emily K. Slotkin,
- Julia L. Glade Bender,
- Neerav N. Shukla,
- Martee L. Hensley,
- John H. Healey,
- Michael P. La Quaglia,
- Kaled M. Alektiar,
- Aimee M. Crago,
- Sam S. Yoon,
- Brian R. Untch,
- Sarah Chiang,
- Narasimhan P. Agaram,
- Meera R. Hameed,
- Michael F. Berger,
- David B. Solit,
- Nikolaus Schultz,
- Marc Ladanyi,
- Samuel Singer,
- William D. Tap
Affiliations
- Benjamin A. Nacev
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Francisco Sanchez-Vega
- Department of Surgery, Memorial Sloan Kettering Cancer Center
- Shaleigh A. Smith
- Department of Surgery, Memorial Sloan Kettering Cancer Center
- Cristina R. Antonescu
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Evan Rosenbaum
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Hongyu Shi
- Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center
- Cerise Tang
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Nicholas D. Socci
- Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center
- Satshil Rana
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Rodrigo Gularte-Mérida
- Department of Surgery, Memorial Sloan Kettering Cancer Center
- Ahmet Zehir
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Mrinal M. Gounder
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Timothy G. Bowler
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Anisha Luthra
- Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center
- Bhumika Jadeja
- Department of Surgery, Memorial Sloan Kettering Cancer Center
- Azusa Okada
- Department of Surgery, Memorial Sloan Kettering Cancer Center
- Jonathan A. Strong
- Department of Surgery, Memorial Sloan Kettering Cancer Center
- Jake Stoller
- Department of Surgery, Memorial Sloan Kettering Cancer Center
- Jason E. Chan
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Ping Chi
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Sandra P. D’Angelo
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Mark A. Dickson
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Ciara M. Kelly
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Mary Louise Keohan
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Sujana Movva
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Katherine Thornton
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Paul A. Meyers
- Department of Pediatrics, Memorial Sloan Kettering Cancer Center
- Leonard H. Wexler
- Department of Pediatrics, Memorial Sloan Kettering Cancer Center
- Emily K. Slotkin
- Department of Pediatrics, Memorial Sloan Kettering Cancer Center
- Julia L. Glade Bender
- Department of Pediatrics, Memorial Sloan Kettering Cancer Center
- Neerav N. Shukla
- Department of Pediatrics, Memorial Sloan Kettering Cancer Center
- Martee L. Hensley
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- John H. Healey
- Department of Surgery, Memorial Sloan Kettering Cancer Center
- Michael P. La Quaglia
- Department of Surgery, Memorial Sloan Kettering Cancer Center
- Kaled M. Alektiar
- Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center
- Aimee M. Crago
- Department of Surgery, Memorial Sloan Kettering Cancer Center
- Sam S. Yoon
- Department of Surgery, Memorial Sloan Kettering Cancer Center
- Brian R. Untch
- Department of Surgery, Memorial Sloan Kettering Cancer Center
- Sarah Chiang
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Narasimhan P. Agaram
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Meera R. Hameed
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Michael F. Berger
- Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center
- David B. Solit
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Nikolaus Schultz
- Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center
- Marc Ladanyi
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Samuel Singer
- Department of Surgery, Memorial Sloan Kettering Cancer Center
- William D. Tap
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- DOI
- https://doi.org/10.1038/s41467-022-30453-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Sarcomas are rare tumours with many different subtypes and clinical outcomes; a broader knowledge of their genetic features is required. Here, the authors analyse 2138 soft tissue and bone sarcomas across 45 subtypes using MSK-IMPACT targeted sequencing and find genomic groups that are distinct from histological subgroups.
