ASSOCIATION BETWEEN PARAMETERS OF CENTRAL AORTIC PRESSURE, OFFICE AND AMBULATORY BLOOD PRESSURE and INDICATORS OF TARGET ORGANS DAMAGE

Abstract

Aim of the study was to investigate in a comparative manner associations between the parameters of central aortic pressure, office and ambulatory blood pressure with indicators of target organ damage. Material and methods. 47 consecutive outpatients and hospital patients (22 men and 25 women) aged 19–70 years were included in the open one-stage follow-up of a series of cases. The study program included anthropometry, measurement of office and ambulatory blood pressure, applanation tonometry of the radial artery, recording of resting ECG, echocardiography, biochemical blood analysis. In analyzing the data, the methods of descriptive statistics and the general linear model (GLM) were used. Results. Central aortic pressure is comparable to office blood pressure and, more than ambulatory blood pressure, was associated with indicators of left ventricular hypertrophy. Systolic central aortic pressure was associated with all electrocardiographic and echocardiographic indices used in the study. Of the central aortic pressure parameters characterizing the amplification and augmentation of the pulse wave, only non-augmented amplification of systolic pressure was associated with signs of left ventricular hypertrophy, but the amplification and augmentation of the pulse wave showed a sufficiently high degree of association with estimated glomerular filtration rate. Conclusion. The results of this study substantiate the relevance of using aortic pressure parameters in addition to traditional methods for determining blood pressure.

Keywords

• central aortic pressure
• target organ damage