Nature Communications (Dec 2019)
Molecular determinants of nephron vascular specialization in the kidney
- David M. Barry,
- Elizabeth A. McMillan,
- Balvir Kunar,
- Raphael Lis,
- Tuo Zhang,
- Tyler Lu,
- Edward Daniel,
- Masataka Yokoyama,
- Jesus M. Gomez-Salinero,
- Angara Sureshbabu,
- Ondine Cleaver,
- Annarita Di Lorenzo,
- Mary E. Choi,
- Jenny Xiang,
- David Redmond,
- Sina Y. Rabbany,
- Thangamani Muthukumar,
- Shahin Rafii
Affiliations
- David M. Barry
- Division of Regenerative Medicine, Ansary Stem Cell Institute, Weill Cornell Medicine
- Elizabeth A. McMillan
- Division of Regenerative Medicine, Ansary Stem Cell Institute, Weill Cornell Medicine
- Balvir Kunar
- Division of Regenerative Medicine, Ansary Stem Cell Institute, Weill Cornell Medicine
- Raphael Lis
- Division of Regenerative Medicine, Ansary Stem Cell Institute, Weill Cornell Medicine
- Tuo Zhang
- Genomics Resources Core Facility, Weill Cornell Medicine
- Tyler Lu
- Division of Regenerative Medicine, Ansary Stem Cell Institute, Weill Cornell Medicine
- Edward Daniel
- Department of Molecular Biology, University of Texas Southwestern Medical Center
- Masataka Yokoyama
- Division of Regenerative Medicine, Ansary Stem Cell Institute, Weill Cornell Medicine
- Jesus M. Gomez-Salinero
- Division of Regenerative Medicine, Ansary Stem Cell Institute, Weill Cornell Medicine
- Angara Sureshbabu
- Division of Nephrology and Hypertension, Weill Cornell Medicine
- Ondine Cleaver
- Department of Molecular Biology, University of Texas Southwestern Medical Center
- Annarita Di Lorenzo
- Pathology and Laboratory Medicine, Weill Cornell Medicine
- Mary E. Choi
- Division of Nephrology and Hypertension, Weill Cornell Medicine
- Jenny Xiang
- Genomics Resources Core Facility, Weill Cornell Medicine
- David Redmond
- Division of Regenerative Medicine, Ansary Stem Cell Institute, Weill Cornell Medicine
- Sina Y. Rabbany
- Division of Regenerative Medicine, Ansary Stem Cell Institute, Weill Cornell Medicine
- Thangamani Muthukumar
- Division of Nephrology and Hypertension, Weill Cornell Medicine
- Shahin Rafii
- Division of Regenerative Medicine, Ansary Stem Cell Institute, Weill Cornell Medicine
- DOI
- https://doi.org/10.1038/s41467-019-12872-5
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
The kidney is vascularized with highly specialized and zonated endothelial cells that are essential for its filtration function. Here, Barry et al. provide a single-cell RNA sequencing analysis of the kidney vasculature that highlights its transcriptional heterogeneity and uncovers pathways important for its development and function.
