P124 VALIDITY AND RELIABILITY OF PULSE WAVE ANALYSIS ESTIMATED BY A NOVEL WRIST-WORN TONOMETER

Abstract

Objective: To analyze the reliability and validity of Pulse Wave Analysis determined with the new wrist-worn tonometry. Methods: Cross sectional study including 254 subjects. Aged 51.9±13.4, being women 53%. Main measurements: Peripheral AIx (PAIx) and Central AIx (CAIx) by wrist-worn tonometry and Sphygmocor. Carotid femoral (cf) pulse wave velocity (PWV) by Sphygmocor, Cardio Anckle Vascular index (CAVI), anckle brachial index (ABI) and brachial anckle (ba) PWV by Vasera device. Carotid intima media thickness (IMT) by ultrasonography. Results: Intra-class correlation coefficient (ICC) intraobserver for the PAIx was 0.886 (95% CI 0.803 to 0.934) and for the CAIx 0.943 (0.901 to 0.968) with a Bland Almant agreement limit of −0.75 (−23.8 to 21.8) and 0.08 (−15.7 to 15.9) respectively. ICC interobserver for PAIx was 0.952 (95% CI 0.915 to 0.972) and CAIx 0.893 (0.811 to 0.939) with an agreement limit of −0.45 (−13.7 to 12.8) and 0.43 (−17.7 to 1835) respectively. We found, compared with Sphygmocor, an ICC of 0.849 (0.798 to 0.887) for PAIx, and 0.783 (0.711 to 0.838) for CAIx. The agreement limit for PAIx was −1.03 (−22.73 to 20.67) and CAIx 2.14 (−20.50 to 24.79). We found positive correlation with PAIx, CAIx and CAIx HR75 by Aurora with age, CAVI, ABI, baPWV, cfPWV, IMT and cardiovascular risk and negative with glomerular filtration rate. Conclusions: The wrist-worn tonometry shows an adequate reliability intra and interobserver, and interdevice when compared to Sphygmocor, and an adequate validity when compared with other measures that evaluate arterial stiffness, target organ damage and cardiovascular risk.