Changes in sleep quality and geriatric-8 (G8) score with chemotherapy in older patients with multiple myeloma

Abstract

Purpose: The aim of this study was to evaluate the sleep quality of older patients with multiple myeloma before and after chemotherapy and investigate factors affecting sleep quality. Materials and Methods: A total of 108 patients with newly diagnosed multiple myeloma were included in the study. Geriatric 8 (G8) and Pittsburgh Sleep Quality Index scores were calculated for the patients at the time of diagnosis, and the changes in these scores were evaluated after three cycles of chemotherapy. Results: At the time of diagnosis, 63 (58.3%) of the patients had sleep disturbances. The sleep disturbance rate decreased to 41.7% after chemotherapy. There was no statistically significant difference in the total G8 score before and after treatment. In logistic regression analyses, the serum calcium level, pre-treatment G8 score, and response to chemotherapy were predictors of sleep quality. Increases in sleep quality were significantly higher in patients with good responses to chemotherapy. Conclusion: Sleep disturbances are a common problem in older patients with multiple myeloma. Our study demonstrated that sleep quality increased with chemotherapy, and patients with low sleep quality had worse responses to treatment. Therefore, there is a need for measures and treatments to increase the sleep quality of these patients.

Keywords

• multiple myeloma
• sleep quality
• geriatric scores
• multiple myelom
• uyku kalitesi
• geriatrik değerlendirme