Nature Communications (Nov 2018)
Serotonin signals through a gut-liver axis to regulate hepatic steatosis
- Wonsuk Choi,
- Jun Namkung,
- Inseon Hwang,
- Hyeongseok Kim,
- Ajin Lim,
- Hye Jung Park,
- Hye Won Lee,
- Kwang-Hyub Han,
- Seongyeol Park,
- Ji-Seon Jeong,
- Geul Bang,
- Young Hwan Kim,
- Vijay K. Yadav,
- Gerard Karsenty,
- Young Seok Ju,
- Chan Choi,
- Jae Myoung Suh,
- Jun Yong Park,
- Sangkyu Park,
- Hail Kim
Affiliations
- Wonsuk Choi
- Graduate School of Medical Science and Engineering, KAIST
- Jun Namkung
- Graduate School of Medical Science and Engineering, KAIST
- Inseon Hwang
- Biomedical Science and Engineering Interdisciplinary Program, KAIST
- Hyeongseok Kim
- Graduate School of Medical Science and Engineering, KAIST
- Ajin Lim
- Graduate School of Medical Science and Engineering, KAIST
- Hye Jung Park
- Department of Internal Medicine, Yonsei University College of Medicine, Yonsei Liver Center, Severance Hospital
- Hye Won Lee
- Department of Internal Medicine, Yonsei University College of Medicine, Yonsei Liver Center, Severance Hospital
- Kwang-Hyub Han
- Department of Internal Medicine, Yonsei University College of Medicine, Yonsei Liver Center, Severance Hospital
- Seongyeol Park
- Graduate School of Medical Science and Engineering, KAIST
- Ji-Seon Jeong
- Center for Bioanalysis, Division of Metrology for Quality of Life, Korea Research Institute of Standards and Science
- Geul Bang
- Biomedical Omics Group, Korea Basic Science Institute
- Young Hwan Kim
- Biomedical Omics Group, Korea Basic Science Institute
- Vijay K. Yadav
- Department of Genetics and Development, Columbia University Medical Center
- Gerard Karsenty
- Department of Genetics and Development, Columbia University Medical Center
- Young Seok Ju
- Graduate School of Medical Science and Engineering, KAIST
- Chan Choi
- Department of Pathology, Chonnam National University Medical School
- Jae Myoung Suh
- Graduate School of Medical Science and Engineering, KAIST
- Jun Yong Park
- Department of Internal Medicine, Yonsei University College of Medicine, Yonsei Liver Center, Severance Hospital
- Sangkyu Park
- Graduate School of Medical Science and Engineering, KAIST
- Hail Kim
- Graduate School of Medical Science and Engineering, KAIST
- DOI
- https://doi.org/10.1038/s41467-018-07287-7
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 9
Abstract
No effective pharmacological treatments exist for nonalcoholic fatty liver disease (NAFLD). Here, the authors show that serotonin concentration in the portal blood is increased in nine human subjects and in mice fed a high-fat diet, and that local serotonin signaling ablation, either genetically or with an antagonist, prevents hepatic steatosis in mice.
