Journal of Translational Medicine (2018-12-01)

Mitochondrial haplogroup H is related to CD4+ T cell recovery in HIV infected patients starting combination antiretroviral therapy

  • Luz M. Medrano,
  • Mónica Gutiérrez-Rivas,
  • Julià Blanco,
  • Marcial García,
  • María A. Jiménez-Sousa,
  • Yolanda M. Pacheco,
  • Marta Montero,
  • José Antonio Iribarren,
  • Enrique Bernal,
  • Onofre Juan Martínez,
  • José M. Benito,
  • Norma Rallón,
  • Salvador Resino,
  • CoRIS and the HIV Biobank integrated in the Spanish AIDS Research Network Project RIS/EPICLIN 10_2015

DOI
https://doi.org/10.1186/s12967-018-1717-y
Journal volume & issue
Vol. 16, no. 1
pp. 1 – 8

Abstract

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Abstract Background The mitochondrial DNA (mtDNA) seems to influence in a large number of diseases, including HIV infection. Moreover, there is a substantial inter-individual variability in the CD4+ recovery in HIV-infected patients on combination antiretroviral therapy (cART). Our study aimed to analyze the association between mtDNA haplogroups and CD4+ recovery in HIV-infected patients on cART. Methods This is a retrospective study of 324 naïve cART patients with CD4+ 9.65 CD4+ cells/mm3/month) than patients without haplogroup H (p = 0.032). The adjusted logistic regression showed that patients carrying haplogroup H had a higher likelihood of achieving a CD4+ recovery > 9.65 CD4+ cells/mm3/month [adjusted odds ratio (aOR) = 1.75 (95% CI = 1.04; 2.95); p = 0.035]. Conclusions European mitochondrial haplogroup H was associated with the improved CD4+ recovery in HIV-infected patients starting cART with CD4+ < 200 cells/mm3.

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