Folia Histochemica et Cytobiologica (Feb 2008)

Genes and structure of selected cytokines involved in pathogenesis of psoriasis.

  • Dorota Krasowska,
  • Paweł Osemlak,
  • Anna Michalak-Stoma,
  • Piotr Nockowski,
  • Grazyna Chodorowska,
  • Anna Zalewska,
  • Aldona Pietrzak

DOI
https://doi.org/10.5603/4455
Journal volume & issue
Vol. 46, no. 1
pp. 11 – 21

Abstract

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Psoriasis is a common skin disease involving 1-4% of human population worldwide, of strong genetic background. The following cytokines are directly involved in psoriasis: TNF, IL-1, IL-2, IL-6, IL-7, IL-8, IL-15, IL-18, IL-19, IL-20, IL-23 whereas IL-4, IL-10, IL-12 as well as IL-11, IL-17 and IFN-gamma are rather indirectly engaged. This work is a review of some genetic factors and structure of selected cytokines and receptors and their genes location.