Nature Communications (Jul 2022)
Sex differences in heart mitochondria regulate diastolic dysfunction
- Yang Cao,
- Laurent Vergnes,
- Yu-Chen Wang,
- Calvin Pan,
- Karthickeyan Chella Krishnan,
- Timothy M. Moore,
- Manuel Rosa-Garrido,
- Todd H. Kimball,
- Zhiqiang Zhou,
- Sarada Charugundla,
- Christoph D. Rau,
- Marcus M. Seldin,
- Jessica Wang,
- Yibin Wang,
- Thomas M. Vondriska,
- Karen Reue,
- Aldons J. Lusis
Affiliations
- Yang Cao
- Division of Cardiology, Department of Medicine, University of California
- Laurent Vergnes
- Metabolism Theme, David Geffen School of Medicine at UCLA
- Yu-Chen Wang
- Division of Cardiology, Department of Medicine, University of California
- Calvin Pan
- Division of Cardiology, Department of Medicine, University of California
- Karthickeyan Chella Krishnan
- Division of Cardiology, Department of Medicine, University of California
- Timothy M. Moore
- Division of Cardiology, Department of Medicine, University of California
- Manuel Rosa-Garrido
- Department of Biomedical Engineering, School of Medicine and School of Engineering, University of Alabama at Birmingham
- Todd H. Kimball
- Department of Anesthesiology & Perioperative Medicine, David Geffen School of Medicine at UCLA
- Zhiqiang Zhou
- Division of Cardiology, Department of Medicine, University of California
- Sarada Charugundla
- Division of Cardiology, Department of Medicine, University of California
- Christoph D. Rau
- Department of Anesthesiology & Perioperative Medicine, David Geffen School of Medicine at UCLA
- Marcus M. Seldin
- Division of Cardiology, Department of Medicine, University of California
- Jessica Wang
- Division of Cardiology, Department of Medicine, University of California
- Yibin Wang
- Department of Anesthesiology & Perioperative Medicine, David Geffen School of Medicine at UCLA
- Thomas M. Vondriska
- Department of Anesthesiology & Perioperative Medicine, David Geffen School of Medicine at UCLA
- Karen Reue
- Metabolism Theme, David Geffen School of Medicine at UCLA
- Aldons J. Lusis
- Division of Cardiology, Department of Medicine, University of California
- DOI
- https://doi.org/10.1038/s41467-022-31544-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
In this paper, the authors show that sex differences in mitochondrial DNA levels and function in the heart contribute to sex biases in functions relevant to heart failure, identifying Acsl6 as a mitochondrial sex-biased regulator of diastolic function.
