Nature Communications (May 2019)

SREBP1 drives Keratin-80-dependent cytoskeletal changes and invasive behavior in endocrine-resistant ERα breast cancer

  • Ylenia Perone,
  • Aaron J. Farrugia,
  • Alba Rodríguez-Meira,
  • Balázs Győrffy,
  • Charlotte Ion,
  • Andrea Uggetti,
  • Antonios Chronopoulos,
  • Pasquale Marrazzo,
  • Monica Faronato,
  • Sami Shousha,
  • Claire Davies,
  • Jennifer H. Steel,
  • Naina Patel,
  • Armando del Rio Hernandez,
  • Charles Coombes,
  • Giancarlo Pruneri,
  • Adrian Lim,
  • Fernando Calvo,
  • Luca Magnani

DOI
https://doi.org/10.1038/s41467-019-09676-y
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 15

Abstract

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ERα breast cancer can relapse to metastatic disease following endocrine therapy. Here, the authors find that when aromatase inhibitor treatment resistance develops, epigenomic reprogramming drives Keratin-80 upregulation via SREBP1, and promotes cytoskeletal rearrangements that drive cancer cell invasion.