Predictive Value of Maternal Serum Magnesium Levels in the Diagnosis of Preterm Labor

Abstract

Background: Preterm labor is the second factor lead to neonatal mortality. Recognizing a test for early detection of preterm labor is essential to prevent neonatal complications. This study aimed to identify the predictive value of maternal serum levels in diagnosis of preterm labor. Methods: In this case-control study, two groups of women with preterm and term labor were enrolled. Data was collected by interviewing with mother, blood tests and clinical examinations. Data were analyzed by using the statistical t and chi-square tests. To determine the specifity and sensitivity, Receiver Operating Characteristic (ROC) was used. Findings: The maternal mean age was 28.60 ± 5.30 years. The gestational age was associated with serum magnesium level. Based on ROC curve, the best cut-off point for maternal serum magnesium level in the gestational age of 32-36 years was 2.25. At this point, the sensitivity was 34%, specifity 92%, positive predictive value 73%, and negative predictive value was 69%. Conclusion: Our result showed that maternal serum magnesium level can be considered as a predictable test for preterm labor. Regarding the cheapness and available of this test, using it is suggested for the prevention of preterm labor.

Keywords

• Magnesium
• Preterm labor
• Sensitivity
• Specifity