Nrf1 promotes heart regeneration and repair by regulating proteostasis and redox balance

Miao Cui; Ayhan Atmanli; Maria Gabriela Morales; Wei Tan; Kenian Chen; Xue Xiao; Lin Xu; Ning Liu; Rhonda Bassel-Duby; Eric N. Olson

doi:10.1038/s41467-021-25653-w

Nature Communications (Sep 2021)

Nrf1 promotes heart regeneration and repair by regulating proteostasis and redox balance

Miao Cui,
Ayhan Atmanli,
Maria Gabriela Morales,
Wei Tan,
Kenian Chen,
Xue Xiao,
Lin Xu,
Ning Liu,
Rhonda Bassel-Duby,
Eric N. Olson

Affiliations

Miao Cui: Department of Molecular Biology, the Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center
Ayhan Atmanli: Department of Molecular Biology, the Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center
Maria Gabriela Morales: Department of Molecular Biology, the Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center
Wei Tan: Department of Molecular Biology, the Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center
Kenian Chen: Quantitative Biomedical Research Center, Department of Population & Data Sciences and Department of Pediatrics, University of Texas Southwestern Medical Center
Xue Xiao: Quantitative Biomedical Research Center, Department of Population & Data Sciences and Department of Pediatrics, University of Texas Southwestern Medical Center
Lin Xu: Quantitative Biomedical Research Center, Department of Population & Data Sciences and Department of Pediatrics, University of Texas Southwestern Medical Center
Ning Liu: Department of Molecular Biology, the Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center
Rhonda Bassel-Duby: Department of Molecular Biology, the Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center
Eric N. Olson: Department of Molecular Biology, the Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center

DOI: https://doi.org/10.1038/s41467-021-25653-w
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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Following injury, cells in regenerative tissues can regrow, but how they adapt to injury conditions to regenerate the tissue is unclear. Here the authors identify a stress-responsive and cardioprotective factor Nrf1 that is critical for neonatal heart regeneration.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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