Remineralization of dentine tubules induced by phosphate-terminated PAMAM dendrimers
Yajie Wen,
Jichao Wang,
Jun Luo,
Jiaojiao Yang
Affiliations
Yajie Wen
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China; School of Environment and Resource, Southwest University of Science and Technology, Mianyang, 621010, China
Jichao Wang
Department of Infection, The People's Hospital of Qiannan, Qiannan, 558000, China
Jun Luo
College of Polymer Science and Engineering, Sichuan University, Chengdu, 610064, China
Jiaojiao Yang
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China; Corresponding author.
Various sealants have been developed to treat the exposure of dentinal tubules (DTs) and further dental hypersensitivity. Herein, the phosphate-terminated fourth generation polyamidoamine dendrimers (PAMAM-PO3H2) was successfully synthesized. Six duplicates of demineralized dentin and type I collagen matrix were incubated in artificial saliva solution with or without PAMAM-PO3H2 treatment at 37 °C for 2 weeks, respectively. The artificial saliva solution was replaced every day. These regenerated crystals on the surface of dentin and collagen matrix were confirmed to be hydroxyapatite (HAp). The approach thus demonstrates that PAMAM-PO3H2 can offer an efficient therapy for seal DTs in clinical dentistry.
