Nature Communications (Apr 2018)

Cathelicidins prime platelets to mediate arterial thrombosis and tissue inflammation

  • Joachim Pircher,
  • Thomas Czermak,
  • Andreas Ehrlich,
  • Clemens Eberle,
  • Erik Gaitzsch,
  • Andreas Margraf,
  • Jochen Grommes,
  • Prakash Saha,
  • Anna Titova,
  • Hellen Ishikawa-Ankerhold,
  • Konstantin Stark,
  • Tobias Petzold,
  • Thomas Stocker,
  • Ludwig T Weckbach,
  • Julia Novotny,
  • Markus Sperandio,
  • Bernhard Nieswandt,
  • Alberto Smith,
  • Hanna Mannell,
  • Barbara Walzog,
  • David Horst,
  • Oliver Soehnlein,
  • Steffen Massberg,
  • Christian Schulz

DOI
https://doi.org/10.1038/s41467-018-03925-2
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 15

Abstract

Read online

Cathelicidins are antimicrobial peptides that eliminate pathogens and contribute to the innate immune response. Here the authors show that neutrophil-derived LL-37/CRAMP induces platelet activation and promotes arterial thrombosis and thrombo-inflammation.