Munc18 and Munc13 serve as a functional template to orchestrate neuronal SNARE complex assembly

Shen Wang; Yun Li; Jihong Gong; Sheng Ye; Xiaofei Yang; Rongguang Zhang; Cong Ma

doi:10.1038/s41467-018-08028-6

Nature Communications (Jan 2019)

Munc18 and Munc13 serve as a functional template to orchestrate neuronal SNARE complex assembly

Shen Wang,
Yun Li,
Jihong Gong,
Sheng Ye,
Xiaofei Yang,
Rongguang Zhang,
Cong Ma

Affiliations

Shen Wang: Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, and the Collaborative Innovation Center for Brain Science, Huazhong University of Science and Technology
Yun Li: Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, and the Collaborative Innovation Center for Brain Science, Huazhong University of Science and Technology
Jihong Gong: Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, and the Collaborative Innovation Center for Brain Science, Huazhong University of Science and Technology
Sheng Ye: National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Xiaofei Yang: Key Laboratory of Cognitive Science, Hubei Key Laboratory of Medical Information Analysis and Tumor Diagnosis and Treatment, Laboratory of Membrane Ion Channels and Medicine, College of Biomedical Engineering, South-Central University for Nationalities
Rongguang Zhang: National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Cong Ma: Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, and the Collaborative Innovation Center for Brain Science, Huazhong University of Science and Technology

DOI: https://doi.org/10.1038/s41467-018-08028-6
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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Synaptic exocytosis depends on formation of the SNARE complex but its assembly mechanism is still under debate. Here, the authors identify an interaction between Munc13-1 and synaptobrevin-2 that is critical for the transition of the Munc18-1/syntaxin-1 complex to the SNARE complex.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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