Marylosides A-G, Norcycloartane Glycosides from Leaves of <i>Cymbidium</i> Great Flower ‘Marylaurencin’

Abstract

Seven novel norcycloartane glycosides, maryloside A−G (1−7), were isolated from the leaves of Cymbidium Great Flower ‘Marylaurencin’, along with a known norcycloartane glycoside, cymbidoside (8). These structures were determined on the basis of mainly NMR experiments as well as chemical degradation and X-ray crystallographic analysis. The isolated compounds (1−6 and 8) were evaluated for the inhibitory activity on lipopolysaccharide (LPS) and interferon-γ (IFN-γ)-stimulated nitric oxide (NO) production in RAW 264.7 cells. Consequently, 1 and 3 exhibited moderate activity.

Keywords

• <i>Cymbidium</i> Great Flower ‘Marylaurencin’
• Orchidaceae
• maryloside
• nitric oxide production
• norcycloartane glycoside