BIMMS: A versatile and portable system for biological tissue and electrode-tissue interface electrical characterization

Abstract

The presented design is a low-cost, compact, and open-source USB-controlled platform for biological tissue and electrode-tissue interface electrical measurements, capable of potentiostatic and galvanostatic electrical impedance spectroscopy up to 10 MHz and cyclic voltammetry with voltage compliance of +−8 V and up to 2.4 mA while ensuring tissue-safety conditions. The data acquisition and generation are based on an Analog Discovery 2 platform (Digilent, USA). We provide accuracy analysis and comparisons with a commercially available calibrated impedance analyzer. Impedance measurements are demonstrated on implanted electrodes for neural stimulation and on an isolated ex-vivo calf brain as an example use case of the presented design.

Keywords

• Impedance spectroscopy
• Potentiostat
• Cyclic voltammetry
• Multisine
• Implantable electrodes
• Electrode-tissue interface