Acute granulomatous interstitial nephritis and ulcerative colitis: a case report and literature review

Abstract

Tubulo-interstitial nephritis (TIN) in patients affected by inflammatory bowel disease, both ulcerative colitis and Crohn’s disease, is usually considered as drug-associated to aminosalicylate. We report a rare case of granulomatous active tubulo-interstitial nephritis in a young patient with a recent diagnosis of ulcerative colitis naïve to aminosalicylate treatment. The patient has been successfully treated with steroids administration. Our purpose is to sensitize that TIN should always to be considered in differential diagnosis an extra-intestinal manifestation of bowel disease.

Keywords

• Aminosalicylate therapy
• inflammatory bowel disease
• tubulo-interstitial nephritis
• steroid therapy.