Xiehe Yixue Zazhi (Sep 2021)

CT-based Radiomics to Predict Recurrence of Bladder Cancer after Resection in One Year: A Preliminary Study

  • ZHANG Gumuyang,
  • XU Lili,
  • MAO Li,
  • LI Xiuli,
  • JIN Zhengyu,
  • SUN Hao

DOI
https://doi.org/10.12290/xhyxzz.2021-0511
Journal volume & issue
Vol. 12, no. 5
pp. 698 – 704

Abstract

Read online

Objective To investigate the feasibility of the CT-based radiomics model to predict the recurrence of bladder cancer in one year postoperatively. Methods Patients with bladder cancer that received surgical treatment in Peking Union Medical College Hospital from May 2014 to July 2018 were retrospectively enrolled and followed up the recurrence of the disease. Nephrographic phase images of preoperative CT urography(CTU) performed in our hospital were collected. The images were filtered before radiomic feature extraction, and JMIM was used to identify the best radiomic features related to recurrence of bladder cancer. Random forest, AdaBoost, gradient boosting, and their combined model were used to build the model for predicting recurrence of bladder cancer after resection in one year. We applied 10-fold cross validation to validate each model and performed receiver operator characteristic curves to analyze the performance of each model. Results A total of 228 cases were included in this study according to inclusion and exclusion criteria. Fifty-one patients had recurrence and the rest 177 patients had no recurrence in one year during postoperative follow-up. In the cross validation, the random forest model, AdaBoost model, gradient boosting model and combined model predicted the recurrence of bladder cancer with AUC of 0.729(95% CI: 0.649-0.809), 0.710(95% CI: 0.627-0.793), 0.709(95% CI: 0.624-0.793)and 0.732(95% CI: 0.651-0.812), accuracy of 76.8%(95% CI: 70.6%-82.0%), 73.7%(95% CI: 67.4%-79.2%), 61.8%(95% CI: 54.7%-67.7%)and 75.0%(95% CI: 68.8%-80.4%), sensitivity of 52.9%(95% CI: 38.6%-66.8%), 62.7%(95% CI: 48.1%-75.5%), 80.4%(95% CI: 64.3%-88.2%)and 58.8%(95% CI: 44.2%-72.1%), specificity of 83.6%(95% CI: 77.1%-88.6%), 76.8%(95% CI: 69.8%-82.7%), 56.5%(95% CI: 48.9%-63.9%)and 79.7%(95% CI: 72.8%-85.2%), respectively. Conclusion Integration of CT-based radiomics prediction models can predict the recurrence risk of bladder cancer in one year postoperatively.

Keywords