Nature Communications (Jul 2019)

Structural definition of a neutralization epitope on the N-terminal domain of MERS-CoV spike glycoprotein

  • Haixia Zhou,
  • Yingzhu Chen,
  • Shuyuan Zhang,
  • Peihua Niu,
  • Kun Qin,
  • Wenxu Jia,
  • Baoying Huang,
  • Senyan Zhang,
  • Jun Lan,
  • Linqi Zhang,
  • Wenjie Tan,
  • Xinquan Wang

DOI
https://doi.org/10.1038/s41467-019-10897-4
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 13

Abstract

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Antibodies that target the N-terminal domain (NTD) of the MERS-CoV spike remain poorly characterized. Here, Zhou et al. report the structural and functional analysis of the NTD-targeting mAb 7D10 and show that it synergizes with antibodies targeting the receptor-binding domain against different MERS-CoV strains.