Frontiers in Physiology (Apr 2012)
The role of inhibitory G proteins and regulators of G protein signalling in the in-vivo control of heart rate and predisposition to cardiac arrhythmias
Abstract
Inhibitory heterotrimeric G-proteins and the control of heart rate.The activation of cell signalling pathways involving inhibitory heterotrimeric G-proteins acts to slow the heart rate via modulation of ion channels. A large number of RGSs can act as GAPs to inhibitory G-proteins and thus it is important to understand the network of RGSG-protein interaction. We will review our recent findings on in-vivo heart rate control in mice with global genetic deletion of various inhibitory G-protein alpha subunits. We will discuss potential central and peripheral contributions to the phenotype and the controversies in the literature.
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