BMC Bioinformatics (Jan 2008)

The comparative analysis of statistics, based on the likelihood ratio criterion, in the automated annotation problem

  • van Houwelingen Hans C,
  • Tokmachev Konstantin Y,
  • Leontovich Andrey M

DOI
https://doi.org/10.1186/1471-2105-9-31
Journal volume & issue
Vol. 9, no. 1
p. 31

Abstract

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Abstract Background This paper discusses the problem of automated annotation. It is a continuation of the previous work on the A4-algorithm (Adaptive algorithm of automated annotation) developed by Leontovich and others. Results A number of new statistics for the automated annotation of biological sequences is introduced. All these statistics are based on the likelihood ratio criterion. Conclusion Some of the statistics yield a prediction quality that is significantly higher (up to 1.5 times higher) in comparison with the results obtained with the A4-procedure.