Genetic Polymorphism of 16 X-STR Loci in Xinjiang Uygur Population
YUAN Chun-yan,
XIA Ruo-cheng,
ZHANG Su-hua,
CHEN Li-qin,
WANG Ya-li,
QU Yi-ling,
YANG Guang-yuan,
DONG Xin-yu,
CHAI Si-yu,
LI Cheng-tao,
TAO Rui-yang
Affiliations
YUAN Chun-yan
Department of Forensic Medicine, Inner Mongolia Medical University, Hohhot 010030, China
XIA Ruo-cheng
Shanghai Key Laboratory of Forensic Medicine, Key Laboratory of Forensic Science, Ministry of Justice, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai 200063, China
ZHANG Su-hua
Shanghai Key Laboratory of Forensic Medicine, Key Laboratory of Forensic Science, Ministry of Justice, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai 200063, China
CHEN Li-qin
Department of Forensic Medicine, Inner Mongolia Medical University, Hohhot 010030, China
WANG Ya-li
Department of Forensic Medicine, Inner Mongolia Medical University, Hohhot 010030, China
QU Yi-ling
Shanghai Key Laboratory of Forensic Medicine, Key Laboratory of Forensic Science, Ministry of Justice, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai 200063, China
YANG Guang-yuan
Department of Forensic Medicine, Inner Mongolia Medical University, Hohhot 010030, China
DONG Xin-yu
Shanghai Key Laboratory of Forensic Medicine, Key Laboratory of Forensic Science, Ministry of Justice, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai 200063, China
CHAI Si-yu
Shanghai Key Laboratory of Forensic Medicine, Key Laboratory of Forensic Science, Ministry of Justice, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai 200063, China
LI Cheng-tao
Department of Forensic Medicine, Inner Mongolia Medical University, Hohhot 010030, China
TAO Rui-yang
Shanghai Key Laboratory of Forensic Medicine, Key Laboratory of Forensic Science, Ministry of Justice, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai 200063, China
ObjectiveTo study the genetic polymorphism and population genetic parameters of 16 X-STR loci in Xinjiang Uygur population.MethodsThe Goldeneye® DNA identification system 17X was used to amplify 16 X-STR loci in 502 unrelated individuals （251 females and 251 males）. The amplified products were detected by 3130xl genetic analyzer. Allele frequencies and population genetic parameters were analyzed statistically. The genetic distances between Uygur and other 8 populations were calculated. Multidimensional scaling and phylogenetic tree were constructed based on genetic distance.ResultsIn the 16 X-STR loci, a total of 67 alleles were detected in 502 Xinjiang Uygur unrelated individuals. The allele frequencies ranged from 0.001 3 to 0.572 4. PIC ranged from 0.568 8 to 0.855 3. The cumulative discrimination power in females and males were 0.999 999 999 999 999 and 0.999 999 999 743 071, respectively. The cumulative mean paternity exclusion chance in trios and in duos were 0.999 999 997 791 859 and 0.999 998 989 000 730, respectively. The genetic distance between Uygur population and Kazakh population was closer, and the genetic distance between Uygur and Han population was farther.ConclusionThe 16 X-STR loci are highly polymorphic and suitable for identification in Uygur population, which can provide a powerful supplement for the study of individual identification, paternity identification and population genetics.
