Frontiers in Cardiovascular Medicine (Aug 2017)

GPla Polymorphisms Are Associated with Outcomes in Patients at High Cardiovascular Risk

  • Dominik Rath,
  • Elke Schaeffeler,
  • Elke Schaeffeler,
  • Stefan Winter,
  • Stefan Winter,
  • Semjon Levertov,
  • Karin Müller,
  • Michal Droppa,
  • Fabian Stimpfle,
  • Harald F. Langer,
  • Meinrad Gawaz,
  • Matthias Schwab,
  • Matthias Schwab,
  • Matthias Schwab,
  • Matthias Schwab,
  • Tobias Geisler

DOI
https://doi.org/10.3389/fcvm.2017.00052
Journal volume & issue
Vol. 4

Abstract

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BackgroundPlatelet membrane glycoprotein receptors mediate thrombus formation. GP Ia/IIa is an essential platelet integrin receptor. Single-nucleotide polymorphisms (SNPs) of the GP Ia/IIa gene alter GP Ia/IIa expression; however, their influence on cardiovascular disease remains unclear. This study aimed to investigate the effect of the GP Ia/IIa SNPs rs1126643 and rs1062535 on clinical outcomes in a large collective including high-risk patients with cardiovascular disease.Methods and resultsGP Ia SNP analysis was performed in 943 patients with symptomatic coronary artery disease. All patients were tracked for all-cause death, myocardial infarction, and ischemic stroke for 360 days. Homozygous carriers of the minor allele showed significantly worse event-free survival when compared with major allele carriers in the complete collective as well as in the subset of high-risk patients (carrying all of the following three risk factors: diabetes type II, hypertension, and hyperlipidemia). There was no significant difference in the subset of low-risk patients (carrying none of the three risk factors).ConclusionsGPla SNPs are associated with cardiovascular prognosis especially in high-risk patients. Identification of GPIa SNPs is of importance to tailor therapies in patients at already high cardiovascular risk.

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