Clinical and epidemiological features of hemorrhagic fever with renal syndrome course in Perm region

Abstract

The results of retrospective analysis of hemorrhagic fever with renal syndrome (HFRS) incidence in the Perm region for 1995–2009 are shown in the article. There are highly active natural foci of infection on the territory of the region, mainly in the subzone of mixed coniferous-deciduous forests. Factors supporting the morbidity are high numbers of small mammals, in particular, the bank vole, with a large circulation of the HFRS virus and active population visit of natural foci in summer-autumn period. Analysis of clinical features of HFRS in 338 patients living in the Perm region, revealed some peculiarities of its course. Among surveyed contingent men (72,4%) prevailed. Most of the patients (80,4%) were of working age (16 to 60 years). More frequently mild and moderate forms (92,8%) of HFRS were observed. A typical picture of the disease with the development of all specific syndromes occurred mainly in patients with severe and moderate forms. Mild cases occurred blurry in the absence of pathognomonic symptoms. Notable was the frequent lesion of liver, with the development of acute anicteric hepatitis (51,2%). Among the complications dominated: pneumonia (4,7%) and acute renal ailure (4,4%). Manifestations of DIC syndrome with recurrent bleeding were registered in 0,6% of patients, toxic shock – at 0,3%. Case fatality rate was 0,6%.

Keywords

• hemorrhagic fever with renal syndrome
• incidence of the disease
• peculiarities of clinical features
• perm region