NR2B GENE EXPRESSION CHANGE IN WISTAR RAT PRACTICING AEROBIC EXERCISE COMPARING TO SOYBEAN (GLYCINE MAX) OR PHYLLANTHUS NIRURI INTAKES AND SOYBEAN AND PHYLLANTHUS NIRURI COMPOSITION INTAKE

Abstract

Objective: To examine the relationship between nutrition and brain memory. Methods: This study was an experimental laboratory study conducted during the period of June 2011 to July 2012 at the Biomedical and Biochemistry laboratory, Faculty of Medicine, Universitas Padjadjaran. The subjects were 56 8-week-old male Wistar rats weighing approximately 200–250 grams which were divided into 8 groups with different treatments. The treatment groups received no exercise or exercise and soybean (Glycine max), Phyllanthus niruri, or combination of both. Results: NR2B gene expression changes found is described as follows: (1) without practicing exercise (3.8) and after exercise (4.6); (2) Glycine max minus exercise (2.86) and Glycine max and exercise (3.17); (3) Phyllanthus niruri minus exercises (4.7) and Phyllanthus niruri and exercise (4.9); and (4) Glycine max and Phyllanthus niruri combination minus exercise (3.14) and Glycine max and Phyllanthus niruri combination and exercise (4.83). Conclusions: This study determines that exercises and Phyllanthus niruri intake enhance NR2B gene expressions. Glycine max inhibits the NR2B gene expressions. Glycine max and Phyllanthus niruri combination, both with and without practicing exercises, enhance NR2B gene expressions. Therefore, practicing exercise and Phyllanthus niruri intake might cause brain cell apoptosis while Glycine max intake inhibits brain cell apoptosis.

Keywords

• Exercise
• gene expressions
• Glycin max
• NR2B
• Phyllanthus niruri