G3: Genes, Genomes, Genetics (Aug 2021)

The genetics of gene expression in a <i>Caenorhabditis elegans</i> multiparental recombinant inbred line population

  • Basten L Snoek,
  • Mark G Sterken,
  • Harm Nijveen,
  • Rita J M Volkers,
  • Joost Riksen,
  • Philip C Rosenstiel,
  • Hinrich Schulenburg,
  • Jan E Kammenga

DOI
https://doi.org/10.1093/g3journal/jkab258
Journal volume & issue
Vol. 11, no. 10

Abstract

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AbstractStudying genetic variation of gene expression provides a powerful way to unravel the molecular components underlying complex traits. Expression quantitative trait locus (eQTL) studies have been performed in several different model species, yet most of these linkage studies have been based on the genetic segregation of two parental alleles. Recently, we developed a multiparental segregating population of 200 recombinant inbred lines (mpRILs) derived from four wild isolates (JU1511, JU1926, JU1931, and JU1941) in the nematode Caenorhabditis eleganstranstranstransC. elegans