Electrochemical Property and Cell Toxicity of Gold Electrode Modified by Monolayer PAMAM Encapsulated Gold Nanorods

Xueqing Zhang; Bifeng Pan; Kan Wang; Jing Ruan; Chenchen Bao; Hao Yang; Rong He; Daxiang Cui

doi:10.5101/nbe.v2i3.p182-188

Nano Biomedicine and Engineering (Sep 2010)

Electrochemical Property and Cell Toxicity of Gold Electrode Modified by Monolayer PAMAM Encapsulated Gold Nanorods

Xueqing Zhang,
Bifeng Pan,
Kan Wang,
Jing Ruan,
Chenchen Bao,
Hao Yang,
Rong He,
Daxiang Cui

Affiliations

Xueqing Zhang: Department of Bio-Nano-Science and Engineering, National Key Laboratory of Nano/Micro Fabrication Technology, Key Laboratory for Thin Film and Microfabrication of Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai Jiao Tong University, Shanghai 200240, China
Bifeng Pan: Department of Bio-Nano-Science and Engineering, National Key Laboratory of Nano/Micro Fabrication Technology, Key Laboratory for Thin Film and Microfabrication of Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai Jiao Tong University, Shanghai 200240, China
Kan Wang: Department of Bio-Nano-Science and Engineering, National Key Laboratory of Nano/Micro Fabrication Technology, Key Laboratory for Thin Film and Microfabrication of Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai Jiao Tong University, Shanghai 200240, China
Jing Ruan: Department of Bio-Nano-Science and Engineering, National Key Laboratory of Nano/Micro Fabrication Technology, Key Laboratory for Thin Film and Microfabrication of Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai Jiao Tong University, Shanghai 200240, China
Chenchen Bao: Department of Bio-Nano-Science and Engineering, National Key Laboratory of Nano/Micro Fabrication Technology, Key Laboratory for Thin Film and Microfabrication of Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai Jiao Tong University, Shanghai 200240, China
Hao Yang: Department of Bio-Nano-Science and Engineering, National Key Laboratory of Nano/Micro Fabrication Technology, Key Laboratory for Thin Film and Microfabrication of Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai Jiao Tong University, Shanghai 200240, China
Rong He: Department of Bio-Nano-Science and Engineering, National Key Laboratory of Nano/Micro Fabrication Technology, Key Laboratory for Thin Film and Microfabrication of Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai Jiao Tong University, Shanghai 200240, China
Daxiang Cui: Department of Bio-Nano-Science and Engineering, National Key Laboratory of Nano/Micro Fabrication Technology, Key Laboratory for Thin Film and Microfabrication of Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai Jiao Tong University, Shanghai 200240, China

DOI: https://doi.org/10.5101/nbe.v2i3.p182-188
Journal volume & issue: Vol. 2, no. 3
pp. 182 – 188

Abstract

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Herein we exploit the molecular engineering capability to immobilize monolayer of polyamidoamine dendrimer on gold electrode, which exhibit enhanced charge transfer and biocompatibility. Polyamidoamine (PAMAM generation 5.0) dendrimers were used as template/stabilizers for gold nanoparticle growth, with Au@PAMAM nanoparticles serving as surface modifier to produce monolayer film. TEM, UV-vis spectroscopy, and AFM were used to characterize the formation of monolayer Au@PAMAM on gold surface. The cyclic voltammetry (CV) and Impedance measurements of Au@PAMAM modified gold electrodes demonstrate electrochemistry properties of modified electrode. Furthermore, Au@PAMAM coating can greatly increased the biocompatibility of gold electrode as determined by cell growth curves

Published in Nano Biomedicine and Engineering

ISSN: 2097-3837 (Print); 2150-5578 (Online)
Publisher: Tsinghua University Press
Country of publisher: China
LCC subjects: Science: Biology (General); Medicine
Website: https://www.sciopen.com/journal/2150-5578

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