Nature Communications (Nov 2016)

Structural and mechanistic insights into regulation of the retromer coat by TBC1d5

  • Da Jia,
  • Jin-San Zhang,
  • Fang Li,
  • Jing Wang,
  • Zhihui Deng,
  • Mark A. White,
  • Douglas G. Osborne,
  • Christine Phillips-Krawczak,
  • Timothy S. Gomez,
  • Haiying Li,
  • Amika Singla,
  • Ezra Burstein,
  • Daniel D. Billadeau,
  • Michael K. Rosen

DOI
https://doi.org/10.1038/ncomms13305
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 11

Abstract

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Retromer is recruited to endosomes by the small GTPase Rab7 and sorting nexin 3. Here, the authors report the interaction between a GTPase-activating protein TBC1d5 and Rab7, examine the biochemical details of the interaction with retromer, and discuss the implications for receptor trafficking.